Protein Details: Acid-sensing ion channel 4

Protein ID

ICDB_Pro_1398

Protein Name

Acid-sensing ion channel 4

Gene Name

ASIC4; ACCN4

Organism

Homo sapiens (Human)

Length

539 amino acids

AlphaFoldDB

AF-Q96FT7-F1-model_v4.pdb

Function

Probable cation channel with high affinity for sodium. In vitro;has no proton-gated channel activity.

Sequence

MPIEIVCKIKFAEEDAKPKEKEAGDEQSLLGAVAPGAAPRDLATFASTSTLHGLGRACGPGPHGLRRTLWALALLTSLAAFLYQAAGLARGYLTRPHLVAMDPAAPAPVAGFPAVTLCNINRFRHSALSDADIFHLANLTGLPPKDRDGHRAAGLRYPEPDMVDILNRTGHQLADMLKSCNFSGHHCSASNFSVVYTRYGKCYTFNADPRSSLPSRAGGMGSGLEIMLDIQQEEYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPWGNCRAESELREPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMPGNETICPPNIYIECADHTLDSLGGGPEGPCFCPTPCNLTRYGKEISMVRIPNRGSARYLARKYNRNETYIRENFLVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLEILDYIYEVSWDRLKRVWRRPKTPLRTSTGGISTLGLQELKEQSPCPSRGRVEGGGVSSLLPNHHHPHGPPGGLFEDFAC

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Dystonia

Location

Expressed in pituitary gland. Weakly expressed in brain;vestibular system and organ of Corti.

DOI ID

10.1097/00001756-200006050-00003; 10.1038/nature03466; 10.1101/gr.2596504; 10.1038/sj.ejhg.5200699

RefSeq

NP_878267.2 [Q96FT7-1]